Jerome Boateng was forced off with an injury midway through the first half or the Champions League final.
Bayern Munich s centre-back went off at half-time with a muscular problem during the semi-final win over Lyon, but started against Paris Saint-Germain in Sunday s showpiece after passing a late fitness test.
However, the 31-year-old managed just 25 minutes before succumbing to an apparent recurrence of the injury he sustained in Bayern s previous outing.
Niklas Sule, who himself has endured an injury-hit campaign, came on as Boateng s replacement, as he did against Lyon.
Get well soon, !
— FC Bayern English (@FCBayernEN)
The change is the earliest a substitution has had to be made in a Champions League final since 2014, when Atletico Madrid s Diego Costa was withdrawn in the ninth minute.
Prior to Boateng s substitution, Neymar had forced a fine double save from Manuel Neuer, while Robert Lewandowski hit the post at the other end of a first half that ended goalless.